The squalene market is projected to increase in value from USD 141 million in 2022 to USD 202 million by 2028, indicating a compound annual growth rate (CAGR) of 6.34% during 2022-2028. The report provides demand analysis, industry insights, competitive intelligence, and customer database with squalene market size, share, growth, demand and future trends with analysis data.

Types of Squalene:

1. Botanical Squalene: Derived from plant sources such as olives, wheat germ, rice bran, and amaranth seed, botanical squalene is the predominant form used in various industries due to its ethical and sustainable sourcing.
2. Animal-derived Squalene: Historically obtained from the livers of deep-sea sharks, this type of squalene has faced increasing scrutiny due to environmental concerns and ethical considerations surrounding shark conservation.

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Recent Developments in the Squalene Market

• In August 2021, Amyris, Inc. launched Rose Inc., a clean color cosmetics brand. The products’ non-comedogenic formulas are developed with proprietary bioengineered and sustainably-sourced ingredients, including squalene and hemisqualane.
• In April 2020, Amyris, Inc. launched the squalene-based hand sanitizer named Pipette under its No Compromise Pipette baby care branded products. The hand sanitizer contains 65% USP plant-based ethyl alcohol, glycerin, and Amyris, Inc.’s sugarcane-derived squalene (for moisturizing benefit).
• In May 2023, Amyris, Inc. signed an exclusive license agreement with British specialty chemicals company Croda International Plc, ("Croda") for the supply of sustainable squalene.
• In July 2023, SOPHIM launched a moisturizing and soothing massage oil. It helps in restoring the skin’s lipidic film, creating a protective barrier that preserves your epidermis from external aggression.
• In June 2023, SOPHIM launched a moisturizing foot mask. The ingredients in this formulation restores the lipid barrier for long-lasting protection against external aggressors and dryness.

Sources of Squalene:

Botanical Sources:

• Olive Oil: Olive oil is a rich source of squalene, with concentrations varying depending on factors such as the olive variety and extraction process.
• Amaranth Seed Oil: Amaranth seed oil contains a significant amount of squalene, making it a valuable source for extraction.
• Rice Bran Oil: Squalene is present in rice bran oil, contributing to its nutritional and functional properties.

Animal Sources:

• Shark Liver Oil: Historically, deep-sea sharks have been the primary source of squalene from animal origins. However, due to sustainability concerns, this source is now less favored.

Functions of Squalene:

1. Biological Functions: Squalene plays a crucial role in various biological processes, including the synthesis of cholesterol, steroid hormones, and vitamin D in humans and animals.
2. Cosmetic Applications: Squalene is widely utilized in the cosmetics industry for its emollient and moisturizing properties. It helps improve skin hydration, elasticity, and overall appearance, making it a common ingredient in skincare products such as moisturizers, serums, and anti-aging formulations.
3. Pharmaceutical Applications: Squalene has potential pharmaceutical applications, including as an adjuvant in vaccine formulations to enhance immune response and as a carrier for drug delivery systems due to its biocompatibility and low toxicity.

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Characterization of Squalene:

1. Chemical Properties: Squalene is a colorless, odorless liquid hydrocarbon with a molecular weight of approximately 410.7 g/mol and a density of around 0.855 g/cm³ at 20°C.
2. Analytical Techniques: Various analytical methods, including gas chromatography (GC), high-performance liquid chromatography (HPLC), and mass spectrometry (MS), are commonly employed to characterize and quantify squalene in different samples.
3. Purity and Quality: The purity of squalene is critical for its various applications. Quality control measures, such as testing for impurities and contaminants, ensure that squalene meets the required standards for safety and efficacy.

End-use Industries:

1. Cosmetics and Personal Care: Squalene is extensively used in the cosmetics and personal care industry, where it serves as a key ingredient in skincare products such as moisturizers, sunscreens, lip balms, and hair conditioners.
2. Pharmaceuticals: In the pharmaceutical sector, squalene finds applications as an adjuvant in vaccine formulations to enhance immune response and as a carrier for drug delivery systems, particularly in the development of lipid-based nanoparticles.
3. Nutraceuticals: Squalene is also utilized in the nutraceutical industry, where it is incorporated into dietary supplements and functional foods for its potential health benefits, including antioxidant properties and support for cardiovascular health.
4. Industrial Applications: Squalene is employed in various industrial applications, such as lubricants, adhesives, and plastics, due to its lubricating properties and biodegradability.

Here's a regional analysis focusing on key areas of squalene production and consumption:

1. Europe:

• Production: Europe accounts for a significant portion of squalene production, primarily sourced from olive oil, wheat germ, and amaranth seed. Countries like Spain, Italy, and Greece are major producers of olive oil, contributing to the region's squalene production.
• Consumption: The European market for squalene is driven by its widespread use in the cosmetics and personal care industry, where it is a common ingredient in skincare products. The region also sees considerable consumption of squalene in pharmaceutical and nutraceutical applications.
• Regulatory Environment: Stringent regulations in the European Union regarding cosmetic ingredients and product safety influence the demand for squalene, with consumers showing a preference for sustainably sourced and environmentally friendly options.

2. Asia-Pacific:

• Production: Countries in the Asia-Pacific region, including China, Japan, and India, are significant producers of botanical squalene, particularly from sources such as rice bran oil and amaranth seed oil. These countries have well-established agricultural sectors that contribute to squalene production.
• Consumption: The Asia-Pacific market for squalene experiences robust demand driven by the cosmetics industry, where squalene is widely used in skincare formulations catering to a large and growing consumer base. Additionally, increasing awareness of the health benefits of squalene fuels its consumption in dietary supplements and functional foods.
• Emerging Markets: Rapid economic growth in emerging markets like China and India presents opportunities for squalene producers and suppliers to expand their presence and tap into growing consumer markets.

3. North America:

• Production: North America, particularly the United States, produces squalene primarily from vegetable sources such as olive oil and soybean oil. The region also imports squalene from other countries to meet domestic demand.
• Consumption: The cosmetics and personal care industry drives squalene consumption in North America, with a focus on natural and sustainable ingredients. Additionally, the pharmaceutical sector utilizes squalene in vaccine adjuvants and drug delivery systems.
• Market Trends: Increasing consumer awareness of the environmental impact of shark-derived squalene has led to a shift towards plant-based alternatives in North America. This trend is expected to continue, with manufacturers and retailers emphasizing sustainability and ethical sourcing practices.

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4. Rest of the World:

• Latin America: Countries like Brazil and Argentina are notable producers of squalene, leveraging their abundant agricultural resources to extract squalene from sources such as olive oil and rice bran oil. The region experiences growing demand for squalene in cosmetics and pharmaceuticals.
• Middle East and Africa: While squalene production in this region is relatively modest, countries like Morocco and Tunisia have significant olive oil industries, contributing to squalene production. The cosmetics and personal care sector drives squalene consumption in the Middle East and Africa, with a focus on premium skincare products.

Squalene Market- Top Manufacturers:

• Amyris, Inc (US)
• SOPHIM (France)
• Merck KGaA (Germany)
• Kishimoto Special Liver Oil Co., Ltd. (Japan)
• Empresa Figueirense De Pesca (Portugal)
• Arbee (India)
• Cibus (US)
• Otto Chemie Pvt. Ltd. (India)
• Arista Industries (US)
• Oleicfat s.l. (Spain)

Merck KGaA operates in a wide range of sectors and offers various products in pharmaceutical and biological prescription drugs to treat cancer, multiple sclerosis (MS), infertility, and growth disorders; cardiovascular and metabolic diseases tools; research-grade chemicals; and equipment for academic labs, biotech, and biopharmaceutical sectors. The company's business can be divided into three main divisions: Healthcare, Life Science, and Electronics. Merck KGaA has a global presence in Europe, North America, Latin America, Africa and Middle East.

Amyris, Inc. is a biotechnology company based in Emeryville, California, United States. The company specializes in synthetic biology and produces a wide range of sustainable and renewable products, primarily using microorganisms and genetic engineering. Amyris Inc operates through three business segments namely; renewable products, licenses and royalties, and collaborations, grants and other. It offers squalene through the renewable products segment. The products of the Amyris Inc., reach more than 300 million consumers in South America, North America, Europe, and Asia Pacific.