North America Botulinum Toxin Market Leading
Growth Drivers, Emerging Audience 2031

The North America Botulinum Toxin Market was valued at US$ 4,801.29 million in 2023 and is expected to reach US$ 12,072.60 million by 2031; it is estimated to register a CAGR of 12.2% from 2023 to 2031.

The North America Botulinum Toxin Market is experiencing growth driven by the expanding range of therapeutic applications for botulinum toxins type A and B. These toxins function by blocking the release of vesicular acetylcholine at neuromuscular and neurosecretory junctions, leading to significant therapeutic benefits in neurorehabilitation. Clinical evidence indicates the effectiveness of botulinum toxins in treating conditions such as headache, sialorrhea (excessive salivation), and hyperhidrosis (excessive sweating). Furthermore, botulinum toxin treatment is emerging as a promising non-surgical alternative for chronic anal fissures and has shown positive outcomes in managing autonomic disorders like ptyalism or gustatory sweating, as well as glandular hypersecretion following parotid gland surgeries.

Beyond these established uses, research highlights the potential of botulinum toxins in assisted reproductive technology. Adequate endometrial growth is critical for successful embryo implantation. Studies suggest that botulinum toxins positively influence the re-epithelialization of human keratinocytes and angiogenesis of endothelial cells. Clinical findings indicate that administering botulinum toxin can aid in the recovery of damaged and impaired thin endometrium by promoting cell proliferation and blood vessel formation, reducing collagen buildup, and ultimately increasing the likelihood of successful embryo implantation. This broadening spectrum of therapeutic applications is expected to shape new trends within the North America Botulinum Toxin Market in the coming years.

North America Botulinum Toxin Market Overview

The North America Botulinum Toxin Market, encompassing the US, Canada, and Mexico, is experiencing growth largely due to the economically stable population and the increasing popularity of non-surgical and minimally invasive cosmetic procedures in these countries. The reduction of facial wrinkles through botulinum toxin injections is the most frequently performed cosmetic procedure in the US and is often the first aesthetic treatment adopted by clinicians. According to the International Society of Aesthetic Plastic Surgery (ISAPS), nearly 2.5 million botulinum toxin procedures were carried out in the US in 2021. Treatments targeting frown lines, crow's feet (both FDA-approved for cosmetic use), and horizontal forehead wrinkles offer predictable results, minimal side effects, and high patient satisfaction. Key commercially available botulinum toxin products in the US include BOTOX Cosmetic/Vistabel (Allergan), Dysport/Azzalure (Galderma and Ipsen), Xeomin/Bocouture (Merz), and Jeuveau (Evolus, manufactured by Daewoong for the US market). The US FDA has approved BOTOX Cosmetic for individuals aged 18–65. The American Society for Aesthetic Plastic Surgery identifies botox injection as the fastest-growing procedure within the cosmetic industry.

Recent regulatory developments further contribute to North America Botulinum Toxin Market growth. In August 2023, the FDA approved Daxxify (daxibotulinumtoxinA-lanm) for its first therapeutic indication: the treatment of adult cervical dystonia. This condition involves involuntary spasms or contractions of neck muscles, leading to abnormal movements, posture, and pain. Affecting approximately 60,000 Americans, cervical dystonia can be managed with botulinum toxin injections that help relax the affected muscles, reducing stiffness and spasms. While the effects are temporary, necessitating repeated treatments, this approval marks a significant expansion in therapeutic applications. Earlier, in July 2021, the FDA approved a label expansion for Allergan's BOTOX Cosmetic, extending its applications to treat eight new muscle conditions associated with upper limb spasticity in adults. These expanding therapeutic uses, alongside the well-established cosmetic applications, are fueling the growth of the North America Botulinum Toxin Market.

North America Botulinum Toxin Market Segments Covered

North America Botulinum Toxin Market By Product

• Botulinum Toxin A and Botulinum Toxin B

North America Botulinum Toxin Market By Application

• Medical and Aesthetic

North America Botulinum Toxin Market By End User

• Specialty & Dermatology Clinics
• Hospitals & Clinics

North America Botulinum Toxin Market Regions and Countries Covered

North America

• US
• Canada
• Mexico

North America Botulinum Toxin Market leaders and key company profiles

• Merz Pharma GmbH & Co KGaA
• AbbVie Inc
• Ipsen SA
• Evolus Inc
• Aquavit
• Revance Therapeutics Inc
• Medytox Inc
• Galderma SA
• Hugel Inc
• Lanzhou Institute of Biological Products Co Ltd

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Author’s Bio:

Suryakant Gadekar

Senior Market Research Expert at Business Market Insights