North America Oligonucleotide Synthesis Market Historical
Analysis, Leading Growth Drivers 2027

The North America Oligonucleotide Synthesis Market is expected to reach US$ $ 1,541.03 Mn in 2027 from US$ 609.90 Mn in 2018. The market is estimated to grow with a CAGR of 11.2% from 2019-2027.

The North America Oligonucleotide Synthesis Market is experiencing growth driven by several key factors. Increased investment in pharmaceutical and biotechnology companies, coupled with funding from government bodies, fuels market expansion. The rising number of market participants and their increasing focus on oligonucleotide synthesis further contribute to this growth.

Oligonucleotides, short single-stranded DNA sequences, are valuable tools in biological applications due to their ability to specifically bind to target DNA sequences. This characteristic makes them essential for identifying the presence of specific genetic material. Their applications span a wide range of fields, including disease diagnosis, biotechnology research, therapeutics, forensics, and drug discovery. Notably, synthetic oligonucleotides play a crucial role in diagnosing human genetic diseases, with oligonucleotide probes capable of detecting even single base pair changes, as exemplified by their use in analyzing sickle cell anemia.

Beyond diagnostics, researchers are leveraging oligonucleotides to develop more efficient and sustainable chemical synthesis methods. By assembling these short sequences into longer fragments encoding synthetic genes, they can instruct bacteria or yeast cells to produce specific enzymes.

Furthermore, oligonucleotides are enabling advancements in therapeutics by offering the potential to target, manipulate, silence, or modulate malfunctioning genes. Companies like Ionis Pharmaceuticals are at the forefront of developing antisense oligonucleotide (ASO) therapeutics, highlighting the promising therapeutic potential of synthesized oligonucleotides. This diverse applicability across various fields is a significant driver of market growth.

NORTH AMERICA OLIGONUCLEOTIDE SYNTHESIS MARKET SEGMENTATION

North America Oligonucleotide Synthesis Market By Product

• Synthesized Oligonucleotides
• Primers
• Probes
• Large-Scale Synthesis
• Others
• Reagents
• Equipment

North America Oligonucleotide Synthesis Market By Application

• Research
• Diagnostics
• Therapeutics

North America Oligonucleotide Synthesis Market By End User

• Academic Research Institutes
• Pharmaceutical & Biotechnology Companies
• Diagnostic Laboratories
• Other End Users

North America Oligonucleotide Synthesis Market By Geography

• North America
• US
• Canada
• Mexico

North America Oligonucleotide Synthesis Market Company Profiles

• Thermo Fisher Scientific Inc.
• GenScript
• Molecular Assemblies
• Twist Biosciences
• Evonetix
• DNA Script
• Nuclera Nucleics
• Camena Bioscience
• Synthomics
• Ansa Biotechnologies

Recent clinical trials, such as those conducted in Canada, are also expected to positively impact the oligonucleotide synthesis market. For instance, a Phase 3 trial initiated in January 2019 enrolled adults with Huntington’s disease in the United States and Canada to evaluate the investigational therapy RG6042 (initially known as IONIS-HTTRx). This antisense oligonucleotide treatment, developed by Ionis Pharmaceuticals and later acquired by Roche, is designed to target and degrade different forms of the mutant huntingtin protein (mHTT), the primary cause of Huntington’s disease. This multi-site trial across five Canadian provinces underscores the growing clinical interest in oligonucleotide-based therapies.

Within North America, the United States is projected to be the leading market. This dominance is attributed to increasing investments and dedicated funding directed towards manufacturing companies, as well as academic and research institutions, for the development of gene synthesis-based end products such as precision medicine and other therapeutics. Considering these factors, the growth of the North America Oligonucleotide Synthesis Market in the US is expected to contribute the largest share within the North American region during the forecast period.

North America Oligonucleotide Synthesis Market Strategic Insights

Strategic insights for the North America Oligonucleotide Synthesis market offer a data-driven analysis of the industry landscape, encompassing current trends, key players, and regional specificities. These insights provide actionable recommendations, empowering stakeholders to differentiate themselves by identifying underserved market segments or developing unique value propositions. By leveraging data analytics, these insights enable industry participants, including investors and manufacturers, to anticipate market shifts. Adopting a future-oriented perspective is crucial, allowing stakeholders to proactively position themselves for long-term success in this dynamic region. Ultimately, effective strategic insights equip readers with the knowledge necessary to make informed decisions that drive profitability and achieve their business objectives within the North America Oligonucleotide Synthesis Market.

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Author’s Bio:

Suryakant Gadekar

Senior Market Research Expert at Business Market Insights