U.S. Single-use Bioprocessing Market Share to Witness Significant Revenue Growth

U.S. Single-use Bioprocessing Market Summary

The U.S. single-use bioprocessing market size was estimated at USD 9.34 billion in 2024 and is projected to grow at a CAGR of 15.04% from 2025 to 2030. The market growth is primarily driven by the rising demand for biopharmaceuticals, which has pushed suppliers to broaden and strengthen their disposable product portfolios. Manufacturers of single-use equipment are continuously innovating to meet the evolving expectations of end users who require flexibility, scalability, and efficiency in their bioprocessing operations. In addition, advancements in bioreactor designs, mixing systems, fluid assemblies, and liner technologies are accelerating the adoption of single-use solutions for biopharmaceutical development and production.

The U.S. single-use bioprocessing industry witnessed a strong positive impact from the COVID-19 pandemic. The surge in demand for vaccines, treatments, and diagnostic assays highlighted the crucial role of single-use systems in enabling rapid scale-up of production. These products ensured sterility, reduced contamination risks, and supported the urgent need for high-throughput biopharmaceutical manufacturing. The pandemic reinforced the strategic importance of disposable systems in ensuring efficient, safe, and scalable production under stringent conditions.

Key Market Trends & Insights

• The simple and peripheral elements segment accounted for the largest market share of 48.54% in 2024. Its growth is supported by ongoing product innovations and the rising relevance of bioprocessing operations in large-scale manufacturing. This segment is expected to expand at the fastest CAGR during the forecast period, as companies increasingly adopt these components to streamline processes and reduce costs.
• The upstream segment dominated the U.S. single-use bioprocessing market with a 57.80% share in 2024 and is forecast to grow at the fastest rate over the coming years. This is attributed to the growing utilization of single-use bioreactors, media bags, and filtration systems by biopharmaceutical manufacturers in the early stages of drug production. Their advantages in scalability, efficiency, and contamination control continue to drive widespread adoption in upstream processes.
• In 2023, biopharmaceutical manufacturers represented the largest share of the end-use segment and are projected to maintain their dominance with the fastest CAGR during the forecast period. Continuous product developments and growing reliance on disposable technologies among in-house manufacturing facilities are fueling the segment’s expansion. The increasing global demand for biologics and biosimilars is further supporting the uptake of single-use systems.
• Academic and clinical research institutes are also anticipated to demonstrate significant growth from 2025 to 2030. This can be attributed to the increasing use of single-use systems in advanced research initiatives focused on developing safe and effective medicines, vaccines, and life-saving therapies. The adaptability and cost-effectiveness of disposable technologies make them highly suitable for experimental and clinical research applications.

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Market Size & Forecast

• 2024 Market Size: USD 9.34 billion
• 2030 Projected Market Size: USD 21.41 billion
• CAGR (2025 - 2030): 15.04%

Key Companies & Market Share Insights

The market players operating in the U.S. single-use bioprocessing industry are undertaking product approvals to expand their product presence and enhance accessibility across various geographical regions. Expansion serves as a strategy to bolster production and research purposes. Moreover, numerous market entities are acquiring smaller firms to improve their market position. This approach enables companies to enhance capabilities, broaden product offerings, and develop new competencies.

Key Players

• Sartorius AG
• Danaher
• Thermo Fisher Scientific, Inc.
• Merck KGaA
• Avantor, Inc.
• Eppendorf SE
• Corning Incorporated
• Meissner Filtration Products, Inc.
• Lonza
• PBS Biotech, Inc.

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Conclusion

The U.S. single-use bioprocessing market is set for substantial expansion as biopharmaceutical demand continues to rise and advanced disposable technologies become integral to production workflows. The market benefits from robust adoption across upstream processes, widespread use among manufacturers, and growing traction in academic research. Continuous innovations in bioreactor systems, liners, and mixing technologies are shaping a more efficient and flexible production ecosystem. The lessons learned from the COVID-19 pandemic further validated the reliability and scalability of single-use systems. Over the forecast period, the market will remain pivotal in enabling rapid, safe, and cost-efficient biopharmaceutical manufacturing, supporting healthcare innovation and patient outcomes.