Backup Compound Strategies: Commercial and Tactical Considerations - Overview

This Insight Pharma Report:  

• Describes how companies are addressing strategic and tactical issues concerning backup compounds and predicts how they are likely to do so in the future
• Provides perspective on best practices to adopt in addressing relevant backup compound issues and how evolution in de-risking technologies may affect those practices
• Presents case histories that illustrate the use of backup compounds in practice
• Examines strategic issues in backup compound selection and utilization, as well as tactical considerations, and investigates trends in the field
• Covers business-related matters that bear significantly on backup strategies and tactics
• Analyzes the results of an extensive Insight Pharma Reports survey conducted among individuals active in commercial small-molecule drug discovery
• Includes complete transcripts of interviews with industry veterans who are highly knowledgeable about backup compound-related issues 

This research begins by considering definitions for backup compounds, reviewing key literature references that present expert views on the topic, and presenting case studies that describe how medicinal chemists approach design and selection of backup compounds. Backup strategies currently in effect, and the types of issues companies consider when deciding whether to designate and advance backup compounds once a drug candidate is selected, are examined. These issues include the necessity for backup compounds; whether backup strategies are ad hoc or policy-based; whether to advance backups based on the same or different chemical scaffold as the prototype; how to best deal with addressing backup compound-related questions before a prototype has advanced to the stage where information needed for such decision-making becomes available; and the role of biomarkers and backup compounds in drug repositioning.

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